Sermorelin
Sermorelin is a lab-made peptide of 29 amino acids, a copy of the first part of a natural hormone called GHRH.
Where it came from
Sermorelin is based on growth hormone-releasing hormone (GHRH), isolated in 1982 by two teams at the Salk Institute in La Jolla, California: Roger Guillemin's group, and the group of Jean Rivier and Wylie Vale.
Both teams found it not in the brain, where they expected it, but in tissue from a pancreatic tumor. Sermorelin is the lab-made version of its first 29 building blocks.
Worth knowing
- Natural GHRH is 44 amino acids long; sermorelin is the first 29, with a small cap on the end. It weighs about 3,358 units.
- Its other name, GRF(1-29)NH2, spells out the same thing: growth hormone-releasing factor, building blocks 1 to 29, with the cap (NH2) on the end.
- Roger Guillemin had already shared the 1977 Nobel Prize in Physiology or Medicine for discovering other releasing hormones made in the brain.
At a glance
| Detail | Value |
|---|---|
| Chain length | 29 amino acids |
| Chemical formula | C149H246N44O42S |
| Weight of one molecule | 3357.9 g/mol |
| Form | Freeze-dried powder |
| Storage | Sealed in a freezer at -20 °C, away from light |
Weight is shown in grams per mole (g/mol), the standard unit chemists use. It's the number a lab checks a sample against to confirm it's the right compound.
Lab reports
Every batch (called a lot) of Sermorelin is tested by an independent lab. The report shows the lab, the test date, the lot number, how pure the sample is and how much is in the vial. Find them on the Certificates of Analysis page. New to lab reports? Start with How to read a peptide lab report.
The weight above is for the compound on its own. A report may show a slightly higher figure, because the powder also carries a little salt left from manufacturing. Peptide salt forms explains why.
Storage
Keep the vial sealed in a freezer at -20 °C, away from light, and let it warm to room temperature before opening so moisture doesn't get in. More in Storing lyophilized (freeze-dried) peptides in the lab and the Research handling guidelines.
For research use only. Not for human or veterinary use.