TB-500
TB-500 is a lab-made peptide modeled on a short section of thymosin beta-4, a natural protein found in most cells.
Where it came from
TB-500 traces back to thymosin beta-4, a natural protein 43 amino acids long. It was decoded in 1981 by Teresa Low, Shu-Kuang Hu and Allan Goldstein at George Washington University in Washington, DC, from an extract of calf thymus, a gland in the chest. It was the second peptide from that extract to have its full makeup worked out.
TB-500 is a later lab-made peptide modeled on a short section of that protein. No single discoverer or naming date is on record.
Worth knowing
- In 1991 thymosin beta-4 turned out to be the same molecule as "Fx", a peptide another lab had found in blood platelets. Two labs had been studying one molecule under two names.
- Thymosin beta-4 grabs onto actin, the protein that forms the internal scaffolding of every cell, one molecule to one. In 1996 researchers pinned down the short section of the chain that does the grabbing.
- The "TB" stands for thymosin beta. Nobody has documented where the "500" came from.
At a glance
| Detail | Value |
|---|---|
| Based on | A short section of thymosin beta-4, a natural protein |
| Form | Freeze-dried powder |
| Storage | Sealed in a freezer at -20 °C, away from light |
Lab reports
Every batch (called a lot) of TB-500 is tested by an independent lab. The report shows the lab, the test date, the lot number, how pure the sample is and how much is in the vial. Find them on the Certificates of Analysis page. New to lab reports? Start with How to read a peptide lab report.
Storage
Keep the vial sealed in a freezer at -20 °C, away from light, and let it warm to room temperature before opening so moisture doesn't get in. More in Storing lyophilized (freeze-dried) peptides in the lab and the Research handling guidelines.
For research use only. Not for human or veterinary use.